Once extracted, open PowerShell (or PowerShell ISE) as an Administrator
Enable PowerShell execution 

Set-ExecutionPolicy Unrestricted -Force

On the prompt, change to the directory where you extracted the files:   
e.g. - cd c:\temp
Next, to run either script, enter in the following:   
e.g. - .\Windows10DebloaterGUI.ps1

How To Run the Windows10Debloater.ps1 and the Windows10DebloaterGUI.ps1 files
There are different methods of running the PowerShell script. The methods are as follows:

First Method
Download the .zip file on the main page of the GitHub and extract the .zip file to your desired location
Once extracted, open PowerShell (or PowerShell ISE) as an Administrator
Enable PowerShell execution Set-ExecutionPolicy Unrestricted -Force
On the prompt, change to the directory where you extracted the files:   e.g. - cd c:\temp
Next, to run either script, enter in the following:   e.g. - .\Windows10DebloaterGUI.ps1
Second Method
Download the .zip file on the main page of the GitHub and extract the .zip file to your desired location
Right-click the PowerShell file that you'd like to run and click on "Run With PowerShell"
This will allow the script to run without having to do the above steps but Powershell will ask if you're sure you want to run this script.
Remember this script NEEDS to be run as admin in order to function properly.

How To Run the Windows10SysPrepDebloater.ps1 file
For the WindowsSysPrepDebloater.ps1 file, there are a couple of parameters that you can run so that you can specify which functions are used. The parameters are: -SysPrep, -Debloat and -Privacy.

To run this with parameters, do the following:

Download the .zip file on the main page of the GitHub and extract the .zip file to your desired location
Once extracted, open PowerShell (or PowerShell ISE) as an Administrator
On the prompt, change to the directory where you extracted the files:   e.g. - cd c:\temp
Next, to run either script, enter in the following:
e.g. - .\Windows10SysPrepDebloater.ps1 -Sysprep -Debloat -Privacy

Sysprep, Interactive, and GUI Application
There are now 3 versions of Windows10Debloater - There is an interactive version, a GUI app version, and a pure silent version.

Windows10SysPrepDebloater.ps1 -> The silent version now utilizes the switch parameters: -Sysprep, -Debloat -Privacy. The silent version can be useful for deploying MDT Images/sysprepping or any other way you deploy Windows 10. This will work to remove the bloatware during the deployment process.

Windows10Debloater.ps1 -> This interactive version is what it implies - a Windows10Debloater script with interactive prompts. This one should not be used for deployments that require a silent script with optional parameters. This script gives you choices with prompts as it runs so that you can make the choices of what the script does.

Windows10DebloaterGUI.ps1 -> There is now a GUI Application named Windows10DebloaterGUI.ps1 with buttons to perform all of the functions that the scripts do. This is better for the average user who does not want to work with code, or if you'd prefer to just see an application screen.

Switch Parameters
There are 3 switch parameters in the Windows10SysPrepDebloater.ps1 script.

-SysPrep, which runs the command within a function: get-appxpackage | remove-appxpackage. This is useful since some administrators need that command to run first in order for machines to be able to properly provision the apps for removal.

-Debloat, switch parameter which does as it suggests. It runs the following functions: Start-Debloat, Remove-Keys, and Protect-Privacy. Remove-Keys removes registry keys leftover that are associated with the bloatware apps listed above, but not removed during the Start-Debloat function.

-Privacy, adds and/or changes registry keys to stop some telemetry functions, stops Cortana from being used as your Search Index, disables "unnecessary" scheduled tasks, and more.